MersV1, Main, Exploration, bibRecord, 004965

Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes

Identifieur interne : 004965 ( Main/Exploration ); précédent : 004964; suivant : 004966

Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes

Auteurs : D. G. Knorre [Russie] ; V. V. Vlassov [Russie]

Source :

Genetica [ 0016-6707 ] ; 1991-01-01.

RBID : ISTEX:B5AE926DF7540913CFB30F185B6F3D19574C5FD7

Descripteurs français

Wicri :
- topic : ADN.

English descriptors

KwdEn :
- Antisense oligonucleotides, DNA, affinity modification.
Teeft :
- Acid, Active compounds, Active oxygen species, Affinity modification, Alkylating, Alkylating derivatives, Alkylating oligonucleotide derivatives, Analog, Antisense, Antisense inhibitors, Antisense oligonucleotides, Antiviral, Antiviral activity, Cell culture, Coding region, Derivative, Dervan, Encephalitis virus, Feb, Febs lett, Gene expression, Helene, Helene toulme, Infectious agents, Inhibitor, Ivanova, Knorre, Lett, Macmillan, Macmillan press, Mamaev, Modification, Mrna, Nucleic, Nucleic acid, Nucleic acid polymerases, Nucleic acids, Nucleotide, Oligonucleotide, Oligonucleotide derivatives, Oligonucleotides, Polymerase, Reactive, Reactive groups, Reactive oligonucleotide derivatives, Reagent, Ribosome, Toulme, Vlassov, Zarytova.

Abstract

Abstract: Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.

Url:

https://api.istex.fr/ark:/67375/1BB-G43F5WTQ-R/fulltext.pdf

DOI: 10.1007/BF00056106

Affiliations:

Russie

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Le document en format XML

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Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes

Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri